C57BL/6 Mouse Bone Marrow Mesenchymal Stem Cells

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Introduction

Bone marrow mesenchymal stem cells (BMSCs) are a type of multipotent stem cell residing in the bone marrow stroma. Due to their strong proliferative capacity and immunomodulatory properties, BMSCs are widely applied in tissue engineering, cell therapy, and gene therapy.

As a research hotspot, C57BL/6 mouse bone marrow mesenchymal stem cells are commonly used in regenerative medicine and tissue engineering, particularly in studies involving bone, cardiovascular, and nervous system disorders.

OriCell™ C57BL/6 Mouse Bone Marrow Mesenchymal Stem Cells are isolated from the bone marrow of healthy C57BL/6 mice. These cells exhibit robust proliferation and multipotent differentiation potential, making them a valuable cell model for studying proliferation, aging, immune regulation, differentiation, and transplantation.

When citing our products in academic journals, please indicate "OriCell™ + Catalog Number, from Cyagen Biosciences (Guangzhou) Inc."

Product Information

Name	OriCell™ C57BL/6 Mouse Bone Marrow Mesenchymal Stem Cells
Catalog Number	MUBMX-01001
Amount of Cells	1×10⁶ cells/vial
Passage Number	P6
Storage at	Liquid Nitrogen（-196℃）

QC

Pass the detection of bacteria, fungi, mycoplasma and endotoxins.
Pass the viability examination. The viable rates is higher than 80%.
The cell doubling time is less than 72 hours.
Flow cytometry showed that CD29, CD44 and Sca-1 are positive (>70%), while CD117 and CD31 are negative (<5%).
The cells can be induced to differentiate into osteoblasts, adipocytes, chondrocytes, etc.

Please refer to "COA" for details.

General Handing Principles

Ensure that all equipment is kept clean and tidy.
Please follow the instructions.
Use suitable and reliable consumables and reagents.
Bone marrow mesenchymal stem cells have limited ability to proliferate in vitro and cannot maintain their differentiation potential for a long time. OriCell™ C57BL/6 Mouse Bone Marrow Mesenchymal Stem Cells can be passaged for more than 5 times and still maintain all indicators qualified. But we always recommend using lower generation cells for scientific research.
Usually the inoculation density of mouse bone marrow mesenchymal stem cells is (2.5~4) ×10⁴live cells/cm².

Warm Notice: The cryopreservation solution of this product contains DMSO, which has potential risks. Please handle it carefully.

Note: This product is intended for research use only and is not for diagnostic, therapeutic, clinical, household, or any other applications.

OriCell-MUBMX-01001-User-Manual.pdf View ››

Suppression of allergic airway inflammation in a mouse model of asthma by exogenous mesenchymal stem cells.
Exp Biol Med (Maywood) 236:1461 (2011 IF = 2.165 　Year 2011
The protective effect of 17b-estradiol against hydrogen peroxide-inducedapoptosis on mesenchymal stem cell.
Biomed Pharmacother 66:57 (2012) IF = 2.023 　Year 2012
LIGHT Regulates the Adipogenic Differentiation of Mesenchymal Stem Cell.
J Cell Biochem 114:346 (2013) IF = 3.368 　Year 2013
Adipocytes regulate the bone marrow microenvironment in a mouse model of obesity.
Mol Med Rep 8:823 (2013) IF = 1.922 　Year 2013
The immunomodulatory effect of bone marrow stromal cells(BMSCs) on interleukin(IL)-23/IL-17-mediated ischemic stroke in mice.
J Neuroimmunol 257:28 (2013) IF = 2.786 　Year 2013
Activation of canonical wnt pathway promotes differentiation of mouse bone marrow-derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro.
J Cell Physiol 228:1270 (2013) IF = 3.874 　Year 2013
MiR-335-5p promotes chondrogenesis in mouse mesenchymal stem cells and is regulated through two positive feedback loops.
J Bone Miner Res 29:1575 (2014) IF = 6.589 　Year 2014
Mesenchymal stem cells ameliorate rhabdomyolysis-induced acute kidney injury via the activation of M2 macrophages.
Stem Cell Res Ther 5:80 (2014) IF = 4.963 　Year 2014
Coregulator CCAR1 positively regulates adipocyte differentiation through the glucocorticoid signaling pathway.
J Biol Chem 289:17078 (2014) IF = 4.6 　Year 2014
Stable Genetic Alterations of b-Catenin and ROR2 Regulate the Wnt Pathway, Affectthe Fate of MSCs.
J Cell Physiol 229:791 (2014) IF = 3.874 　Year 2014
Effects of bone marrow‑derived mesenchymal stem cells transfected with survivin on pulmonary fibosis in mice.
Exp Ther Med 10:1857 (2015) IF = 1.269 　Year 2015
MSCs Modiﬁed With ACE2 Restore Endothelial Function Following LPS Challenge by Inhibiting the Activation of RAS.
J Cell Physiol 230:691 (2015) IF = 3.839 　Year 2015
Second-harmonic generation microscopy for assessment of mesenchymal stem cell-seeded acellular dermal matrix in wound-healing.
Biomaterials 53:659 (2015) IF = 8.557 　Year 2015
MicroRNA-133b negatively regulates the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.
Int J Clin Exp Pathol 9(12):12609-12614 (2016) IF = 1.581 　Year 2016
Protective Effect of bFGF on Bone Marrow Mesenchymal Stem Cell against Hydrogen Peroxide-Induced Apoptosis.
Open Access Library Journal DOI: 10.4236/oalib.1102393 　Year 2016
Functional differences between AMPK α1 and α2 subunits in osteogenesis, osteoblast-associated induction of osteoclastogenesis, and adipogenesis.
Sci Rep PMID:27600021 (2016） IF = 5.228 　Year 2016
Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/β-catenin signaling pathway in vivo and in vitro.
Sci Rep PMID:27029606 (2016） IF = 5.228 　Year 2016
Generation of non-viral, transgene-free hepatocyte like cells with piggyBac transposon.
Scientific Reports 7:44498 (2017) IF = 4.259 　Year 2017
Inducible Metabolic Adaptation Promotes Mesenchymal Stem Cell Therapy for Ischemia.
Arterioscler Thromb Vasc Biol 34 (4):870-6 (2014) IF = 6.607 　Year 2014
MSCs on an acellular dermal matrix (ADM) sourced from neonatal mouse skin regulate collagen reconstruction of granulation tissue during adult cutaneous wound healing.
RSC Advances 22998-23010 (2017) IF = 3.108 　Year 2017
Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53.
STEM CELLS 35:1760–1772 (2017) IF = 5.599 　Year 2017
Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material.
Biomaterials 139:39-55 (2017) IF = 8.402 　Year 2017
Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application.
Materials Science and Engineering C 73:347-356 (2017) IF = 4.164 　Year 2017
Hepatic differentiation of mouse bone marrow‑derived mesenchymal stem cells using a novel 3D culture system.
Mol Med Rep 16:9473-9479 (2017) IF = 1.922 　Year 2017
Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs.
BMC Musculoskeletal Disorders 18:423 (2017) IF = 1.739 　Year 2017
Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to the Adipose Lineage.
Endocrinology 158:3109–3125 (2017) IF = 4.286 　Year 2017
Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell (BMSC) Differentiation through an Estrogen Receptor-Mediated Pathway.
BioMed Research International 2018:4178021 (2018) IF = 2.583 　Year 2018
3D‐Printed Microrobotic Transporters with Recapitulated Stem Cell Niche for Programmable and Active Cell Delivery.
Adv Funct Mater DOI:10.1002/adfm.201808992 (2019) IF = 13.325 　Year 2019
CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint.
Nature Communications DOI: 10.1038/s41467-019-14060-x (2020) IF = 11.878 　Year 2020
Mesenchymal stem cells regulate the Th17/Treg cell balance partly through hepatocyte growth factor in vitro.
Stem Cell Research & Therapy 11: 91 (2020) IF = 4.627 　Year 2020
High-mobility group box 1 protein antagonizes the immunosuppressive capacity and therapeutic effect of mesenchymal stem cells in acute kidney injury.
Journal of Translational Medicine PMID: 32312307 (2020) IF = 4.098 　Year 2020
Loading of Metal Isotope-Containing Intercalators for Mass Cytometry-Based High-Throughput Quantitation of Exosome Uptake at the Single-Cell Level.
Biomaterials DOI: 10.1016/j.biomaterials.2020.120152 IF = 10.273 　Year 2020
Extracellular vesicles from bone marrow mesenchymal stem cells alleviate acute rejection injury after liver transplantation by carrying miR-22-3p and inducing M2 polarization of Kupffer cells.
JOURNAL OF GENE MEDICINE IF = 4.152 　Year 2023

Complete Medium For Mouse Bone Marrow Mesenchymal Stem Cells

Complete Medium For Mouse Bone Marrow Mesenchymal Stem Cells (Without EXO)

Osteogenic Differentiation Medium For Mouse Bone Marrow Mesenchymal Stem Cells

Adipogenic Differentiation Medium For Mouse Bone Marrow Mesenchymal Stem Cells

Chondrogenic Differentiation Medium For Mouse Bone Marrow Mesenchymal Stem Cells

C57BL/6 Mouse Bone Marrow Mesenchymal Stem Cell Exosomes

C57BL/6 Mouse Bone Marrow Mesenchymal Stem Cells With GFP

C57BL/6 Mouse Bone Marrow Mesenchymal Stem Cells With RFP

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