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266-6 Mouse Pancreatic Acinar Carcinoma Cell Line
Introduction
The mouse pancreatic acinar cell carcinoma cell line (266-6) was established in 1985 by Robert E. Hammer. It was derived from epithelial-like cells isolated from the pancreas of an adult mouse bearing a pancreatic acinar cell tumor and is widely used for transfection studies. This cell line retains a partially differentiated phenotype that closely resembles the original tumor's characteristics. It expresses detectable levels of various digestive enzyme mRNAs and responds to carbachol and cholecystokinin, but not to substance P, secretin, or vasoactive intestinal peptide (VIP).
OriCell™ 266-6 Mouse Pancreatic Acinar Carcinoma Cell Line is primarily used to investigate the pathogenesis of pancreatic cancer, perform drug screening, and develop therapeutic strategies. Because these cells preserve pancreatic acinar cell characteristics and secrete pancreatic enzymes, they are commonly employed in studies of exocrine pancreatic function and related diseases. For example, 266-6 cells are frequently used to study the role of KRAS mutations in pancreatic carcinogenesis or to screen novel chemotherapeutic agents targeting pancreatic cancer.
When citing our products in academic publications, please use the following format: "OriCell™ [Product Name] + [Catalog Number], from Cyagen Biosciences."
Product Information
| Name | OriCell™ 266-6 Mouse Pancreatic Acinar Carcinoma Cell Line |
| Alternative Name | —— |
| Catalog Number | M2-1201 |
| Amount of Cells | 1×106 cells/vial |
| Tissue Origin | Mouse Pancreas |
| Cell Characteristics | Adherent Growth; Epithelial-like (Round, Irregular, Polygonal shape) |
| Culture Conditions | 95% air; 5% CO2; 37 ℃ |
| Culture Medium | DMEM + 10% FBS |
| Doubling Time | 12~24 h |
| Biosafety Level | 2 |
| Storage at | Liquid Nitrogen (-196 ℃) |
| Precautions | —— |
QC
- Tested for bacteria, fungi, mycoplasma, and endotoxins.
- Tested for cell viability and recovery.
- Confirmed by short tandem repeat (STR) analysis.
Please refer to "COA" for details.
General Handling Principles
- Strict sterile environment. Ensure the cleanliness of the entire laboratory, laminar flow hood, and incubator.
- Follow standardized operating procedures. Adhere to the instructions described in the product manual, strictly control variables, and conduct appropriate control experiments.
- Use appropriate and high-quality consumables and reagents. This product requires culture vessels suitable for adherent cell growth, and their reuse is not recommended. The reagents used must be validated for reliability, suitable for cell growth, and exhibit minimal batch-to-batch variation.
